Inhibition of RNA polymerase III transcription by Triptolide attenuates colorectal tumorigenesis

Abstract Background Upregulation of RNA polymerase (Pol) III products, including tRNAs and 5S rRNA, in tumor cells leads to enhanced protein synthesis and tumor formation, making it a potential target for cancer treatment. In this study, we evaluated the inhibition of Pol III transcription by tripto...

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Main Authors: Xia Liang, Renxiang Xie, Jinfeng Su, Bingqi Ye, Saisai Wei, Zhibing Liang, Rongpan Bai, Zhanghui Chen, Zhongxiang Li, Xiangwei Gao
Formato: Artigo
Idioma:Inglês
Publicado: BMC 2019-05-01
Series:Journal of Experimental & Clinical Cancer Research
Assuntos:
Triptolide
Colorectal cancer
RNA polymerase III
TFIIIB
Acceso en liña:http://link.springer.com/article/10.1186/s13046-019-1232-x
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