Genome engineering via homologous recombination in mouse embryonic stem (ES) cells: an amazingly versatile tool for the study of mammalian biology

The ability to introduce genetic modifications in the germ line of complex organisms has been a long-standing goal of those who study developmental biology. In this regard, the mouse, a favorite model for the study of the mammals, is unique: indeed not only is it possible since the late seventies, t...

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Библиографические подробности
Главные авторы: CHARLES BABINET, MICHEL COHEN-TANNOUDJI
Формат: Artigo
Язык:Inglês
Опубликовано: Academia Brasileira de Ciências 2001-09-01
Серии:Anais da Academia Brasileira de Ciências
Предметы:
células-tronco embrionárias
genoma
mira genética
camundongos ''knock out''
mutações condicionais
embryonic stem cells (ES)
genome
gene ''targeting''
knock-out mice
conditional mutations
Online-ссылка:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652001000300007
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