Genome engineering via homologous recombination in mouse embryonic stem (ES) cells: an amazingly versatile tool for the study of mammalian biology

The ability to introduce genetic modifications in the germ line of complex organisms has been a long-standing goal of those who study developmental biology. In this regard, the mouse, a favorite model for the study of the mammals, is unique: indeed not only is it possible since the late seventies, t...

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Bibliografiske detaljer
Main Authors: CHARLES BABINET, MICHEL COHEN-TANNOUDJI
Format: Artigo
Sprog:Inglês
Udgivet: Academia Brasileira de Ciências 2001-09-01
Serier:Anais da Academia Brasileira de Ciências
Fag:
células-tronco embrionárias
genoma
mira genética
camundongos ''knock out''
mutações condicionais
embryonic stem cells (ES)
genome
gene ''targeting''
knock-out mice
conditional mutations
Online adgang:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652001000300007
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