Oxygen Desaturation Is Associated With Fibrocyte Activation via Epidermal Growth Factor Receptor/Hypoxia-Inducible Factor-1α Axis in Chronic Obstructive Pulmonary Disease

Fibrocytes are bloodborne mesenchymal progenitors which accumulate and differentiate at the disease site. We investigated whether hypoxemia activates fibrocytes, accelerating airflow limitation and exercise intolerance in chronic obstructive pulmonary disease (COPD) patients. Flow cytometry was used...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Päätekijät: Chun-Hua Wang, Chun-Yu Lo, Hung-Yu Huang, Tsai-Yu Wang, Chih-Ming Weng, Chih-Jung Chen, Yu-Chen Huang, Fu-Tsai Chung, Chang-Wei Lin, Kian Fan Chung, Han-Pin Kuo
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Frontiers Media S.A. 2022-05-01
Sarja:Frontiers in Immunology
Aiheet:
chronic obstructive pulmonary disease (COPD)
fibrocyte
epidermal growth factor receptor (EGFR)
hypoxia-inducible factor-1α (HIF-1α)
desaturation
Linkit:https://www.frontiersin.org/articles/10.3389/fimmu.2022.852713/full
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