Oxygen Desaturation Is Associated With Fibrocyte Activation via Epidermal Growth Factor Receptor/Hypoxia-Inducible Factor-1α Axis in Chronic Obstructive Pulmonary Disease

Fibrocytes are bloodborne mesenchymal progenitors which accumulate and differentiate at the disease site. We investigated whether hypoxemia activates fibrocytes, accelerating airflow limitation and exercise intolerance in chronic obstructive pulmonary disease (COPD) patients. Flow cytometry was used...

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Hauptverfasser: Chun-Hua Wang, Chun-Yu Lo, Hung-Yu Huang, Tsai-Yu Wang, Chih-Ming Weng, Chih-Jung Chen, Yu-Chen Huang, Fu-Tsai Chung, Chang-Wei Lin, Kian Fan Chung, Han-Pin Kuo
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2022-05-01
Schriftenreihe:Frontiers in Immunology
Schlagworte:
chronic obstructive pulmonary disease (COPD)
fibrocyte
epidermal growth factor receptor (EGFR)
hypoxia-inducible factor-1α (HIF-1α)
desaturation
Online Zugang:https://www.frontiersin.org/articles/10.3389/fimmu.2022.852713/full
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