Oxygen Desaturation Is Associated With Fibrocyte Activation via Epidermal Growth Factor Receptor/Hypoxia-Inducible Factor-1α Axis in Chronic Obstructive Pulmonary Disease

Fibrocytes are bloodborne mesenchymal progenitors which accumulate and differentiate at the disease site. We investigated whether hypoxemia activates fibrocytes, accelerating airflow limitation and exercise intolerance in chronic obstructive pulmonary disease (COPD) patients. Flow cytometry was used...

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Bibliografiske detaljer
Main Authors: Chun-Hua Wang, Chun-Yu Lo, Hung-Yu Huang, Tsai-Yu Wang, Chih-Ming Weng, Chih-Jung Chen, Yu-Chen Huang, Fu-Tsai Chung, Chang-Wei Lin, Kian Fan Chung, Han-Pin Kuo
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2022-05-01
Serier:Frontiers in Immunology
Fag:
chronic obstructive pulmonary disease (COPD)
fibrocyte
epidermal growth factor receptor (EGFR)
hypoxia-inducible factor-1α (HIF-1α)
desaturation
Online adgang:https://www.frontiersin.org/articles/10.3389/fimmu.2022.852713/full
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