Oxygen Desaturation Is Associated With Fibrocyte Activation via Epidermal Growth Factor Receptor/Hypoxia-Inducible Factor-1α Axis in Chronic Obstructive Pulmonary Disease

Fibrocytes are bloodborne mesenchymal progenitors which accumulate and differentiate at the disease site. We investigated whether hypoxemia activates fibrocytes, accelerating airflow limitation and exercise intolerance in chronic obstructive pulmonary disease (COPD) patients. Flow cytometry was used...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Chun-Hua Wang, Chun-Yu Lo, Hung-Yu Huang, Tsai-Yu Wang, Chih-Ming Weng, Chih-Jung Chen, Yu-Chen Huang, Fu-Tsai Chung, Chang-Wei Lin, Kian Fan Chung, Han-Pin Kuo
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Frontiers Media S.A. 2022-05-01
Cyfres:Frontiers in Immunology
Pynciau:
chronic obstructive pulmonary disease (COPD)
fibrocyte
epidermal growth factor receptor (EGFR)
hypoxia-inducible factor-1α (HIF-1α)
desaturation
Mynediad Ar-lein:https://www.frontiersin.org/articles/10.3389/fimmu.2022.852713/full
Tagiau: Ychwanegu Tag
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