Modelling combined virotherapy and immunotherapy: strengthening the antitumour immune response mediated by IL-12 and GM-CSF expression

Combined virotherapy and immunotherapy has been emerging as a promising and effective cancer treatment for some time. Intratumoural injections of an oncolytic virus instigate an immune reaction in the host, resulting in an influx of immune cells to the tumour site. Through combining an oncolytic vir...

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Main Authors: Adrianne L. Jenner, Chae-Ok Yun, Arum Yoon, Adelle C. F. Coster, Peter S. Kim
Formato: Artigo
Idioma:Inglês
Publicado: Intercollegiate Biomathematics Alliance 2018-06-01
Series:Letters in Biomathematics
Assuntos:
Mathematical biology
oncolytic virotherapy
immunotherapy
IL-12
GM-CSF
Acceso en liña:http://dx.doi.org/10.1080/23737867.2018.1438216
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