Antibodies to a Citrullinated Porphyromonas gingivalis Epitope Are Increased in Early Rheumatoid Arthritis, and Can Be Produced by Gingival Tissue B Cells: Implications for a Bacterial Origin in RA Etiology

Based on the epidemiological link between periodontitis and rheumatoid arthritis (RA), and the unique feature of the periodontal bacterium Porphyromonas gingivalis to citrullinate proteins, it has been suggested that production of anti-citrullinated protein antibodies (ACPA), which are present in a...

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Main Authors: Natalia Sherina, Charlotte de Vries, Nastya Kharlamova, Natalie Sippl, Xia Jiang, Boel Brynedal, Elin Kindstedt, Monika Hansson, Linda Mathsson-Alm, Lena Israelsson, Ragnhild Stålesen, Saedis Saevarsdottir, Rikard Holmdahl, Aase Hensvold, Gunnar Johannsen, Kaja Eriksson, Federica Sallusto, Anca I. Catrina, Johan Rönnelid, Caroline Grönwall, Tülay Yucel-Lindberg, Lars Alfredsson, Lars Klareskog, Luca Piccoli, Vivianne Malmström, Khaled Amara, Karin Lundberg
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2022-04-01
Series:Frontiers in Immunology
Subjects:
rheumatoid arthritis (RA)
anti-citrullinated protein antibodies (ACPA)
Porphyromonas gingivalis (Pg)
periodontitis (PD)
monoclonal antibodies (mAbs)
B cells
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.804822/full
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