A Bacterially Expressed SARS-CoV-2 Receptor Binding Domain Fused With Cross-Reacting Material 197 A-Domain Elicits High Level of Neutralizing Antibodies in Mice

The Coronavirus disease 2019 (COVID-19) pandemic presents an unprecedented public health crisis worldwide. Although several vaccines are available, the global supply of vaccines, particularly within developing countries, is inadequate, and this necessitates a need for the development of less expensi...

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Main Authors: Liqin Liu, Tingting Chen, Lizhi Zhou, Jie Sun, Yuqian Li, Meifeng Nie, Hualong Xiong, Yuhe Zhu, Wenhui Xue, Yangtao Wu, Tingting Li, Tianying Zhang, Zhibo Kong, Hai Yu, Jun Zhang, Ying Gu, Qingbing Zheng, Qinjian Zhao, Ningshao Xia, Shaowei Li
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2022-04-01
Serier:Frontiers in Microbiology
Fag:
SARS-CoV-2
receptor binding domain
CRM197 A domain
Escherichia coli expression system
adjuvant
vaccine
Online adgang:https://www.frontiersin.org/articles/10.3389/fmicb.2022.854630/full
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