TOOme: A Novel Computational Framework to Infer Cancer Tissue-of-Origin by Integrating Both Gene Mutation and Expression

Metastatic cancers require further diagnosis to determine their primary tumor sites. However, the tissue-of-origin for around 5% tumors could not be identified by routine medical diagnosis according to a statistics in the United States. With the development of machine learning techniques and the acc...

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Bibliographic Details
Main Authors: Binsheng He, Jidong Lang, Bo Wang, Xiaojun Liu, Qingqing Lu, Jianjun He, Wei Gao, Pingping Bing, Geng Tian, Jialiang Yang
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2020-05-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
tissue-of-origin
somatic mutation
gene expression
random forest
cross-validation
Online Access:https://www.frontiersin.org/article/10.3389/fbioe.2020.00394/full
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