Assessing the causal role of epigenetic clocks in the development of multiple cancers: a Mendelian randomization study

Background: Epigenetic clocks have been associated with cancer risk in several observational studies. Nevertheless, it is unclear whether they play a causal role in cancer risk or if they act as a non-causal biomarker. Methods: We conducted a two-sample Mendelian randomization (MR) study to examine...

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Autori principali: Fernanda Morales Berstein, Daniel L McCartney, Ake T Lu, Konstantinos K Tsilidis, Emmanouil Bouras, Philip Haycock, Kimberley Burrows, Amanda I Phipps, Daniel D Buchanan, Iona Cheng, the PRACTICAL consortium, Richard M Martin, George Davey Smith, Caroline L Relton, Steve Horvath, Riccardo E Marioni, Tom G Richardson, Rebecca C Richmond
Natura: Artigo
Lingua:Inglês
Pubblicazione: eLife Sciences Publications Ltd 2022-03-01
Serie:eLife
Soggetti:
cancer
epigenetic age acceleration
Mendelian randomization
epigenetic clocks
epidemiology
DNA methylation
Accesso online:https://elifesciences.org/articles/75374
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