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Integrating genetic and nongenetic drivers of somatic evolution during carcinogenesis: The biplane model
Abstract The multistep transition from a normal to a malignant cellular phenotype is often termed “somatic evolution” caused by accumulating random mutations. Here, we propose an alternative model in which the initial genetic state of a cancer cell is the result of mutations that occurred throughout...
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| Главные авторы: | , , , |
|---|---|
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Wiley
2020-08-01
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| Серии: | Evolutionary Applications |
| Предметы: | |
| Online-ссылка: | https://doi.org/10.1111/eva.12973 |
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