Structural basis of α-catenin recognition by EspB from enterohaemorrhagic E. coli based on hybrid strategy using low-resolution structural and protein dissection.

Enterohaemorrhagic E. coli (EHEC) induces actin reorganization of host cells by injecting various effectors into host cytosol through type III secretion systems. EspB is the natively partially folded EHEC effector which binds to host α-catenin to promote the actin bundling. However, its structural b...

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Autores principales: Mitsuhide Hamaguchi, Hironari Kamikubo, Kayo N Suzuki, Yoshihisa Hagihara, Itaru Yanagihara, Ikuhiro Sakata, Mikio Kataoka, Daizo Hamada
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science (PLoS) 2013-01-01
Colección:PLoS ONE
Acceso en línea:http://europepmc.org/articles/PMC3743801?pdf=render
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