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Pharmacophore modeling for anti-Chagas drug design using the fragment molecular orbital method.
Chagas disease, caused by the parasite Trypanosoma cruzi, is a neglected tropical disease that causes severe human health problems. To develop a new chemotherapeutic agent for the treatment of Chagas disease, we predicted a pharmacophore model for T. cruzi dihydroorotate dehydrogenase (TcDHODH) by f...
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Autori principali: | , , , , , , , , , , , , , , |
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Natura: | Artigo |
Lingua: | Inglês |
Pubblicazione: |
Public Library of Science (PLoS)
2015-01-01
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Serie: | PLoS ONE |
Accesso online: | http://europepmc.org/articles/PMC4427443?pdf=render |
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