Wird geladen...

Structure and Molecular Dynamics Simulations of Protein Tyrosine Phosphatase Non-Receptor 12 Provide Insights into the Catalytic Mechanism of the Enzyme

Protein tyrosine phosphatase non-receptor 12 (PTPN12) is an important protein tyrosine phosphatase involved in regulating cell adhesion and migration as well as tumorigenesis. Here, we solved a crystal structure of the native PTPN12 catalytic domain with the catalytic cysteine (residue 231) in dual...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Hui Dong, Francesco Zonta, Shanshan Wang, Ke Song, Xin He, Miaomiao He, Yan Nie, Sheng Li
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI AG 2017-12-01
Schriftenreihe:International Journal of Molecular Sciences
Schlagworte:
Online Zugang:https://www.mdpi.com/1422-0067/19/1/60
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!