Structure and Molecular Dynamics Simulations of Protein Tyrosine Phosphatase Non-Receptor 12 Provide Insights into the Catalytic Mechanism of the Enzyme

Protein tyrosine phosphatase non-receptor 12 (PTPN12) is an important protein tyrosine phosphatase involved in regulating cell adhesion and migration as well as tumorigenesis. Here, we solved a crystal structure of the native PTPN12 catalytic domain with the catalytic cysteine (residue 231) in dual...

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Autores principales: Hui Dong, Francesco Zonta, Shanshan Wang, Ke Song, Xin He, Miaomiao He, Yan Nie, Sheng Li
Formato: Artigo
Lenguaje:Inglês
Publicado: MDPI AG 2017-12-01
Colección:International Journal of Molecular Sciences
Materias:
PTPN12
molecular dynamics
structure
Acceso en línea:https://www.mdpi.com/1422-0067/19/1/60
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