Dissociation of GLP-1 and insulin association with food processing in the brain: GLP-1 sensitivity despite insulin resistance in obese humans

Objective: Glucagon-like peptide-1 (GLP-1) is released into the bloodstream after food intake. In addition to stimulating insulin release, it causes satiety and contributes to the termination of food intake. In this study, we investigated whether endogenous GLP-1 affects food-related brain activity...

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Autori principali: Martin Heni, Stephanie Kullmann, Baptist Gallwitz, Hans-Ulrich Häring, Hubert Preissl, Andreas Fritsche
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2015-12-01
Serie:Molecular Metabolism
Soggetti:
Glucagon-like peptide-1
Incretin
Brain
fMRI
Orbitofrontal cortex
Brain insulin resistance
Accesso online:http://www.sciencedirect.com/science/article/pii/S2212877815001775
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