Acacetin protects against cerebral ischemia-reperfusion injury via the NLRP3 signaling pathway

Acacetin (5,7-dihydroxy-4′-methoxyflavone), a potential neuroprotective agent, has an inhibitory effect on lipopolysaccharide-induced neuroinflammatory reactions. However, whether acacetin has an effect on inflammatory corpuscle 3 (NLRP3) after cerebral ischemia-reperfusion injury has not been fully...

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Bibliographic Details
Main Authors: Juan Bu, Shen Shi, Hui-Qin Wang, Xiao-Shan Niu, Zong-Feng Zhao, Wei-Dong Wu, Xiao-Ling Zhang, Zhi Ma, Yan-Jun Zhang, Hui Zhang, Yi Zhu
Format: Artigo
Language:Inglês
Published: Wolters Kluwer Medknow Publications 2019-01-01
Series:Neural Regeneration Research
Subjects:
nerve regeneration; acacetin; cerebral ischemia-reperfusion injury; microglia; NLRP3 inflammasome; inflammatory factor; infarct volume; signaling pathway; nuclear factor-κB; neuroprotection; neural regeneration
Online Access:http://www.nrronline.org/article.asp?issn=1673-5374;year=2019;volume=14;issue=4;spage=605;epage=612;aulast=Bu
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