Role of inducible nitric oxide synthase pathway on methotrexate-induced intestinal mucositis in rodents

<p>Abstract</p> <p>Background</p> <p>Methotrexate treatment has been associated to intestinal epithelial damage. Studies have suggested an important role of nitric oxide in such injury. The aim of this study was to investigate the role of nitric oxide (NO), specifically...

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Autors principals: Siqueira Francisco JWS, Lima-Júnior Roberto CP, Gomes Antoniella S, Silva Johann V, Bellaguarda Emmanuelle AL, Braga-Neto Manuel B, Oriá Reinaldo B, Brito Gerly AC, Leitão Renata FC, Freire Rosemeyre S, Vale Mariana L, Ribeiro Ronaldo A
Format: Artigo
Idioma:Inglês
Publicat: BMC 2011-08-01
Col·lecció:BMC Gastroenterology
Matèries:
Nitric oxide
Nitric oxide synthase
Methotrexate
Aminoguanidine
Nφ-Nitro-L-arginine methyl ester
Accés en línia:http://www.biomedcentral.com/1471-230X/11/90
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