Hippo component YAP promotes focal adhesion and tumour aggressiveness via transcriptionally activating THBS1/FAK signalling in breast cancer

Abstract Background Focal adhesion plays an essential role in tumour invasiveness and metastasis. Hippo component YAP has been widely reported to be involved in many aspects of tumour biology. However, its role in focal adhesion regulation in breast cancer remains unexplored. Methods Tissue microarr...

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Hlavní autoři: Jie Shen, Beibei Cao, Yatao Wang, Chenshen Ma, Zhuo Zeng, Liang Liu, Xiaolan Li, Deding Tao, Jianping Gong, Daxing Xie
Médium: Artigo
Jazyk:Inglês
Vydáno: BMC 2018-07-01
Edice:Journal of Experimental & Clinical Cancer Research
Témata:
Breast cancer
Focal adhesion
YAP
THBS1
FAK
On-line přístup:http://link.springer.com/article/10.1186/s13046-018-0850-z
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