A G-Protein-Coupled Receptor Modulates Gametogenesis via PKG-Mediated Signaling Cascade in Plasmodium berghei

ABSTRACT Gametogenesis is essential for malaria parasite transmission, but the molecular mechanism of this process remains to be refined. Here, we identified a G-protein-coupled receptor 180 (GPR180) that plays a critical role in signal transduction during gametogenesis in Plasmodium. The P. berghei...

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Hlavní autoři: Peng-peng Wang, Xuefeng Jiang, Liying Zhu, Dan Zhou, Mingyang Hong, Lu He, Lumeng Chen, Shijie Yao, Yan Zhao, Guang Chen, Chengqi Wang, Liwang Cui, Yaming Cao, Xiaotong Zhu
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2022-04-01
Edice:Microbiology Spectrum
Témata:
malaria
G-protein-coupled receptor
gametogenesis
signal transduction
transmission-blocking activity
On-line přístup:https://journals.asm.org/doi/10.1128/spectrum.00150-22
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