Up-Regulation of HMGB1 Exacerbates Renal Ischemia-Reperfusion Injury by Stimulating Inflammatory and Immune Responses through the TLR4 Signaling Pathway in Mice

Background/Aims: The aim of this study was to elucidate how high-mobility group box 1 (HMGB1) exacerbates renal ischemic-reperfusion injury (IRI) by inflammatory and immune responses through the toll-like receptor 4 (TLR4) signaling pathway. Methods: A total of 30 wild-type (WT) mice and 30 TLR4 kno...

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Autori principali: Chuan-Bao Chen, Long-Shan Liu, Jian Zhou, Xiao-Ping Wang, Ming Han, Xing-Yuan Jiao, Xiao-Shun He, Xiao-Peng Yuan
Natura: Artigo
Lingua:Inglês
Pubblicazione: Cell Physiol Biochem Press GmbH & Co KG 2017-05-01
Serie:Cellular Physiology and Biochemistry
Soggetti:
High-mobility group box 1
Toll-like receptor 4 signaling pathway
Renal ischemic-reperfusion injury
Inflammatory response
Immune response
Accesso online:http://www.karger.com/Article/FullText/475914
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