Proprotein Convertase Subtilisin/Kexin Type 9, Brain Cholesterol Homeostasis and Potential Implication for Alzheimer’s Disease

Alzheimer’s disease (AD) has been associated with dysregulation of brain cholesterol homeostasis. Proprotein convertase subtilisin/kexin type 9 (PCSK9), beyond the known role in the regulation of plasma low-density lipoprotein cholesterol, was first identified in the brain with a potential involveme...

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Autori principali: Maria Pia Adorni, Massimiliano Ruscica, Nicola Ferri, Franco Bernini, Francesca Zimetti
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2019-05-01
Serie:Frontiers in Aging Neuroscience
Soggetti:
PCSK9 (proprotein convertase subtilisin/kexin type 9)
Alzheimer
cholesterol
apolipoprotein E
neuron
brain
Accesso online:https://www.frontiersin.org/article/10.3389/fnagi.2019.00120/full
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