Imepitoin Shows Benzodiazepine-Like Effects in Models of Anxiety

Imepitoin is a low affinity partial agonist for the benzodiazepine binding site of γ-aminobutyric acid (GABAA) receptors, and is currently used as an antiepileptic in dogs. Here we tested imepitoin for anxiolytic properties. In an in vitro model, imepitoin was capable of preventing the effect of cor...

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Hlavní autoři: Odilo Engel, Aleksandar Masic, Gary Landsberg, Melissa Brooks, Daniel S. Mills, Chris Rundfeldt
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2018-11-01
Edice:Frontiers in Pharmacology
Témata:
anxiolytic
imepitoin
in vitro
in vivo
dog
mouse
On-line přístup:https://www.frontiersin.org/article/10.3389/fphar.2018.01225/full
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