Imepitoin Shows Benzodiazepine-Like Effects in Models of Anxiety

Imepitoin is a low affinity partial agonist for the benzodiazepine binding site of γ-aminobutyric acid (GABAA) receptors, and is currently used as an antiepileptic in dogs. Here we tested imepitoin for anxiolytic properties. In an in vitro model, imepitoin was capable of preventing the effect of cor...

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Detaylı Bibliyografya
Asıl Yazarlar: Odilo Engel, Aleksandar Masic, Gary Landsberg, Melissa Brooks, Daniel S. Mills, Chris Rundfeldt
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Frontiers Media S.A. 2018-11-01
Seri Bilgileri:Frontiers in Pharmacology
Konular:
anxiolytic
imepitoin
in vitro
in vivo
dog
mouse
Online Erişim:https://www.frontiersin.org/article/10.3389/fphar.2018.01225/full
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