Gonadectomy in Mito-Ob mice revealed a sex-dimorphic relationship between prohibitin and sex steroids in adipose tissue biology and glucose homeostasis

Abstract Background Recently, we have developed a novel transgenic mouse model by overexpressing prohibitin (PHB) in adipocytes, which developed obesity due to upregulation of mitochondrial biogenesis in adipocytes, hence named “Mito-Ob.” Interestingly, only male Mito-Ob mice developed obesity-relat...

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Bibliografiska uppgifter
Huvudupphovsmän: Yang Xin Zi Xu, Sudharsana Rao Ande, Suresh Mishra
Materialtyp: Artigo
Språk:Inglês
Publicerad: BMC 2018-08-01
Serie:Biology of Sex Differences
Ämnen:
Prohibitin
Obesity
Adipocyte differentiation
17β-estradiol
Testosterone
Sex differences
Länkar:http://link.springer.com/article/10.1186/s13293-018-0196-4
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