Nat1 Deficiency Is Associated with Mitochondrial Dysfunction and Exercise Intolerance in Mice

We recently identified human N-acetyltransferase 2 (NAT2) as an insulin resistance (IR) gene. Here, we examine the cellular mechanism linking NAT2 to IR and find that Nat1 (mouse ortholog of NAT2) is co-regulated with key mitochondrial genes. RNAi-mediated silencing of Nat1 led to mitochondrial dysf...

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Main Authors: Indumathi Chennamsetty, Michael Coronado, Kévin Contrepois, Mark P. Keller, Ivan Carcamo-Orive, John Sandin, Giovanni Fajardo, Andrew J. Whittle, Mohsen Fathzadeh, Michael Snyder, Gerald Reaven, Alan D. Attie, Daniel Bernstein, Thomas Quertermous, Joshua W. Knowles
Formato: Artigo
Idioma:Inglês
Publicado: Elsevier 2016-10-01
Series:Cell Reports
Assuntos:
NAT2
Nat1
insulin resistance
mitochondrial dysfunction
adipose tissue
fatty acids
mitochondria
basal metabolic rate
reactive oxygen species
Acceso en liña:http://www.sciencedirect.com/science/article/pii/S2211124716312104
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