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Hypoxia-induced pulmonary hypertension and chronic lung disease: caveolin-1 dysfunction an important underlying feature

Caveolin-1 (cav-1) has been shown to play a significant role in the pathogenesis of pulmonary hypertension (PH). In the monocrotaline model of PH, the loss of endothelial cav-1 as well as reciprocal activation of proliferative and anti-apoptotic pathways initiate the disease process and facilitate i...

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Main Authors: Jing Huang, Maria Frid, Michael H. Gewitz, John T. Fallon, Dale Brown, Greta Krafsur, Kurt Stenmark, Rajamma Mathew
Formáid: Artigo
Teanga:Inglês
Foilsithe: SAGE Publishing 2019-03-01
Sraith:Pulmonary Circulation
Rochtain Ar Líne:https://doi.org/10.1177/2045894019837876
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