Cerebrovascular amyloid Angiopathy in bioengineered vessels is reduced by high-density lipoprotein particles enriched in Apolipoprotein E

Abstract Background Several lines of evidence suggest that high-density lipoprotein (HDL) reduces Alzheimer’s disease (AD) risk by decreasing vascular beta-amyloid (Aβ) deposition and inflammation, however, the mechanisms by which HDL improve cerebrovascular functions relevant to AD remain poorly un...

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Bibliographic Details
Main Authors: Jerome Robert, Emily B. Button, Emma M. Martin, Luke McAlary, Zoe Gidden, Megan Gilmour, Guilaine Boyce, Tara M. Caffrey, Andrew Agbay, Amanda Clark, Judith M. Silverman, Neil R. Cashman, Cheryl L. Wellington
Format: Artigo
Language:Inglês
Published: BMC 2020-03-01
Series:Molecular Neurodegeneration
Subjects:
Alzheimer’s disease
Cerebrovasculature
High-density lipoprotein (HDL)
Cerebral amyloid angiopathy (CAA)
Endothelial inflammation
Apolipoprotein (apo)E
Online Access:http://link.springer.com/article/10.1186/s13024-020-00366-8
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