Peripheral Immune Activation in Mice Elicits Unfolded Protein Responses Independent on MyD88 Pathway in the Liver but not the Hypothalamus and Hippocampus

Neuroimmune interactions between the immune system and CNS as well as peripheral organs such as the liver play a key role in the pathophysiological state of diseases. Unfolded protein responses (UPRs), which are activated by cells in response to endoplasmic reticulum stress, have been linked to the...

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Bibliographic Details
Main Authors: Yosuke Yamawaki, Hitomi Kimura, Susumu Nagata, Koichiro Ozawa, Toru Hosoi
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2022-04-01
Series:Frontiers in Physiology
Subjects:
unfolded protein response
ER stress
myeloid differentiation primary response 88
lipopolysaccharide
brain
hypothalamus
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2022.854538/full
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