Molecular Lesions of Insulator CTCF and Its Paralogue CTCFL (BORIS) in Cancer: An Analysis from Published Genomic Studies

CTCF (CCCTC-binding factor) is a transcription regulator with hundreds of binding sites in the human genome. It has a main function as an insulator protein, defining together with cohesins the boundaries of areas of the genome called topologically associating domains (TADs). TADs contain regulatory...

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Bibliographic Details
Main Author: Ioannis A. Voutsadakis
Format: Artigo
Language:Inglês
Published: MDPI AG 2018-10-01
Series:High-Throughput
Subjects:
CTCF
CTCFL
BORIS
insulator
cancer
mutations
amplifications
topologically associating domains
Online Access:http://www.mdpi.com/2571-5135/7/4/30
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