Esculetin and Fucoidan Attenuate Autophagy and Apoptosis Induced by Zinc Oxide Nanoparticles through Modulating Reactive Astrocyte and Proinflammatory Cytokines in the Rat Brain

We examined the protective effects of esculetin and fucoidan against the neurotoxicity of ZnO NPs in rats. Ninety rats were divided into nine groups and pre-treated with esculetin or fucoidan 1 h before ZnO NP administration on a daily basis for 2 weeks. Serum and brain homogenates were examined by...

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Bibliographic Details
Main Authors: Woo-Ju Song, Jeongtae Kim, Taekyun Shin, Myeong-Seon Jeong, Kil-Nam Kim, Jang-Hyuk Yun, Myung-Bok Wie
Format: Artigo
Language:Inglês
Published: MDPI AG 2022-04-01
Series:Toxics
Subjects:
lipoxygenase
tumor necrosis factor-α
beclin-1
glial fibrillary acidic protein
hippocampus
Online Access:https://www.mdpi.com/2305-6304/10/4/194
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