Liraglutide Activates mTORC1 Signaling and AMPA Receptors in Rat Hippocampal Neurons Under Toxic Conditions

The aim of the present study was to determine whether treatment with liraglutide, a glucagon-like peptide 1 (GLP-1) receptor agonist, would alter mammalian target of rapamycin complex 1 (mTORC1) signaling and/or α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptor activity under dexa...

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Autores principales: Sung Woo Park, Rodrigo B. Mansur, Yena Lee, Jae-Hon Lee, Mi Kyoung Seo, Ah Jeong Choi, Roger S. McIntyre, Jung Goo Lee
Formato: Artigo
Lenguaje:Inglês
Publicado: Frontiers Media S.A. 2018-10-01
Colección:Frontiers in Neuroscience
Materias:
mammalian target of rapamycin complex 1 signaling
α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor
glucagon-like peptide 1 receptor
liraglutide
neuroplasticity
toxic condition
Acceso en línea:https://www.frontiersin.org/article/10.3389/fnins.2018.00756/full
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