Identification of Novel Covalent XPO1 Inhibitors Based on a Hybrid Virtual Screening Strategy

Nuclear export protein 1 (XPO1), a member of the nuclear export protein-p (Karyopherin-P) superfamily, regulates the transport of “cargo” proteins. To facilitate this important process, which is essential for cellular homeostasis, XPO1 must first recognize and bind the cargo proteins. To inhibit thi...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Main Authors: Zheyuan Shen, Weihao Zhuang, Kang Li, Yu Guo, Bingxue Qu, Sikang Chen, Jian Gao, Jing Liu, Lei Xu, Xiaowu Dong, Jinxin Che, Qimeng Li
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2022-04-01
Serier:Molecules
Fag:
nuclear export protein 1
hybrid virtual screening
covalent docking
anti-tumor
Online adgang:https://www.mdpi.com/1420-3049/27/8/2543
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker