RIPK1 suppresses apoptosis mediated by TNF and caspase-3 in intervertebral discs

Abstract Background Low back pain has become a serious social and economic burden and the leading cause of disability worldwide. Among a variety of pathophysiological triggers, intervertebral disc (IVD) degeneration plays a primary underlying role in causing such pain. Specifically, multiple indepen...

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Hlavní autoři: Xubin Qiu, Ming Zhuang, Ziwen Lu, Zhiwei Liu, Dong Cheng, Chenlei Zhu, Jinbo Liu
Médium: Artigo
Jazyk:Inglês
Vydáno: BMC 2019-04-01
Edice:Journal of Translational Medicine
Témata:
Intervertebral disc
Degeneration
Apoptosis
RIPK1
On-line přístup:http://link.springer.com/article/10.1186/s12967-019-1886-3
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