COS-7-based model: methodological approach to study John Cunningham virus replication cycle

Abstract John Cunningham virus (JCV) is a human neurotropic polyomavirus whose replication in the Central Nervous System (SNC) induces the fatal demyelinating disease, progressive multifocal leukoencephalopathy (PML). JCV propagation and PML investigation have been severely hampered by the lack of a...

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Bibliographic Details
Main Authors: C. Prezioso, D. Scribano, D. M. Rodio, C. Ambrosi, M. Trancassini, A. T. Palamara, V. Pietropaolo
Format: Artigo
Language:Inglês
Published: BMC 2018-02-01
Series:Virology Journal
Subjects:
COS-7 cell line
JCV
Infection
Q-PCR
VP1
Western blot
Online Access:http://link.springer.com/article/10.1186/s12985-018-0939-1
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