COS-7-based model: methodological approach to study John Cunningham virus replication cycle

Abstract John Cunningham virus (JCV) is a human neurotropic polyomavirus whose replication in the Central Nervous System (SNC) induces the fatal demyelinating disease, progressive multifocal leukoencephalopathy (PML). JCV propagation and PML investigation have been severely hampered by the lack of a...

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Main Authors: C. Prezioso, D. Scribano, D. M. Rodio, C. Ambrosi, M. Trancassini, A. T. Palamara, V. Pietropaolo
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2018-02-01
Serier:Virology Journal
Fag:
COS-7 cell line
JCV
Infection
Q-PCR
VP1
Western blot
Online adgang:http://link.springer.com/article/10.1186/s12985-018-0939-1
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