Lipophilic Constituents in Salvia miltiorrhiza Inhibit Activation of the Hepatic Stellate Cells by Suppressing the JAK1/STAT3 Signaling Pathway: A Network Pharmacology Study and Experimental Validation

Liver fibrosis is currently a global health challenge with no approved therapy, with the activation of hepatic stellate cells being a principal factor. Lipophilic constituents in Salvia miltiorrhiza (LS) have been reported to improve liver function and reduce the indicators of liver fibrosis for pat...

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Main Authors: Ya-Xin Tang, Mingming Liu, Long Liu, Bo-Rui Zhen, Tian-Tian Wang, Na Li, Nanning Lv, Zhenyu Zhu, Guoquan Sun, Xiaobo Wang, Si Chen
Formáid: Artigo
Teanga:Inglês
Foilsithe: Frontiers Media S.A. 2022-04-01
Sraith:Frontiers in Pharmacology
Ábhair:
Salvia miltiorrhiza
hepatic stellate cells
liver fibrosis
network pharmacology
JAK1/STAT3 signaling pathway
Rochtain Ar Líne:https://www.frontiersin.org/articles/10.3389/fphar.2022.770344/full
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