Momordica. charantia-Derived Extracellular Vesicles-Like Nanovesicles Protect Cardiomyocytes Against Radiation Injury via Attenuating DNA Damage and Mitochondria Dysfunction

Thoracic radiotherapy patients have higher risks of developing radiation-induced heart disease (RIHD). Ionizing radiation generates excessive reactive oxygens species (ROS) causing oxidative stress, while Momordica. charantia and its extract have antioxidant activity. Plant-derived extracellular ves...

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Main Authors: Wen-Wen Cui, Cong Ye, Kai-Xuan Wang, Xu Yang, Pei-Yan Zhu, Kan Hu, Ting Lan, Lin-Yan Huang, Wan Wang, Bing Gu, Chen Yan, Ping Ma, Su-Hua Qi, Lan Luo
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2022-04-01
Serier:Frontiers in Cardiovascular Medicine
Fag:
Momordica. charantia-derived extracellular vesicles-like nanovesicles
radiation-induced heart disease
DNA damage
mitochondria dysfunction
H9C2 cells
Online adgang:https://www.frontiersin.org/articles/10.3389/fcvm.2022.864188/full
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