Chronic Microglial Activation in the GFAP-IL6 Mouse Contributes to Age-Dependent Cerebellar Volume Loss and Impairment in Motor Function

Chronic microglial activation is a prominent feature of many chronic neurodegenerative diseases, including Parkinson’s and Alzheimer’s disease. To investigate the effects of chronic microglial activation on cerebellar structure and motor function throughout the lifespan, the transgenic GFAP-IL6 mous...

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Autors principals: Erika Gyengesi, Alejandra Rangel, Faheem Ullah, Huazheng Liang, Garry Niedermayer, Rustam Asgarov, Madhuri Venigalla, Dhanushka Gunawardena, Tim Karl, Gerald Münch
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2019-04-01
Col·lecció:Frontiers in Neuroscience
Matèries:
chronic microglia activation
motor function
degeneration
interleukin-6
cerebellum
microglia
Accés en línia:https://www.frontiersin.org/article/10.3389/fnins.2019.00303/full
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