Expression and Effect of Inhibition of the Ubiquitin-Conjugating Enzyme E2C on Esophageal Adenocarcinoma

Ubiquitin-dependent proteolysis of cyclins plays a critical role in cell cycle progression and tumorigenesis. We examined the expression of ubiquitin-conjugating enzyme E2C (UBE2C) during progression from Barrett's metaplasia to esophageal adenocarcinoma (EA) and the effects of targeting this e...

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Main Authors: Jules Lin, Duna A. Raoof, Zhuwen Wang, Mu-Yen Lin, Dafydd G. Thomas, Joel K. Greenson, Thomas J. Giordano, Mark B. Orringer, Andrew C. Chang, David G. Beer, Lin Lin
Format: Artigo
Jezik:Inglês
Izdano: Elsevier 2006-12-01
Serija:Neoplasia: An International Journal for Oncology Research
Teme:
Esophageal adenocarcinoma
ubiquitin
UBE2C
proteasome inhibitor
siRNA
Online dostop:http://www.sciencedirect.com/science/article/pii/S1476558606801120
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