Direct Oral Anticoagulants vs. Vitamin-K Antagonists in the Elderly With Atrial Fibrillation: A Systematic Review Comparing Benefits and Harms Between Observational Studies and Randomized Controlled Trials

Background: The publication of high-quality observational studies (OSs) has fueled reassessment of the treatment effects of direct oral anticoagulants (DOACs) in the elderly with atrial fibrillation (AF).Methods: The MEDLINE, EMBASE, and Cochrane Library databases were systematically searched (throu...

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Главные авторы: Nan-Nan Shen, Yue Wu, Na Wang, Ling-Cong Kong, Chi Zhang, Jia-Liang Wang, Zhi-Chun Gu, Jin Chen
Формат: Artigo
Язык:Inglês
Опубликовано: Frontiers Media S.A. 2020-09-01
Серии:Frontiers in Cardiovascular Medicine
Предметы:
stroke
embolism
bleeding
real-world study
warfarin
dabigatran
Online-ссылка:https://www.frontiersin.org/article/10.3389/fcvm.2020.00132/full
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