Synthesis and Regularities of the Structure–Activity Relationship in a Series of <i>N</i>-Pyridyl-4-methyl-2,2-dioxo-1<i>H</i>-2λ<sup>6</sup>,1-benzothiazine-3-carboxamides

According to our quantum and chemical calculations 4-methyl-2,2-dioxo-1<i>H</i>-2&#955;<sup>6</sup>,1-benzothiazine-3-carboxylic acid imidazolide is theoretically almost as reactive as its 2-carbonyl analog, and it forms the corresponding <i>N</i>-pyridyl-4-me...

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Hauptverfasser: Igor V. Ukrainets, Anna A. Burian, Ganna M. Hamza, Natali I. Voloshchuk, Oxana V. Malchenko, Svitlana V. Shishkina, Lyudmila V. Sidorenko, Kateryna O. Burian, Galina Sim
Format: Artigo
Sprache:Inglês
Veröffentlicht: Österreichische Apotheker-Verlagsgesellschaft m. b. H. 2019-05-01
Schriftenreihe:Scientia Pharmaceutica
Schlagworte:
4-methyl-2,2-dioxo-1<i>H</i>-2λ<sup>6</sup>,1-benzothiazine-3-carboxamide
2,1-benzothiazine
aminopyridines
crystal structure
molecular conformation
analgesic activity
anti-inflammatory action
Online Zugang:https://www.mdpi.com/2218-0532/87/2/12
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