Role of Notch1 in the arterial specification and angiogenic potential of mouse embryonic stem cell-derived endothelial cells

Abstract Background Endothelial cells have been shown to mediate angiogenesis in ischemic injury sites and contribute to the repair of damaged tissues. However, the treatment of ischemic disease requires a significant number of endothelial cells, which are difficult to isolate from patients. Embryon...

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Bibliographic Details
Main Authors: Jae Kyung Park, Tae Wook Lee, Eun Kyoung Do, Hye Ji Moon, Jae Ho Kim
Format: Artigo
Language:Inglês
Published: BMC 2018-07-01
Series:Stem Cell Research & Therapy
Subjects:
Notch1
Mouse embryonic stem cell
Endothelial cell
Angiogenesis
Peripheral artery disease
Hindlimb ischemia
Online Access:http://link.springer.com/article/10.1186/s13287-018-0945-7
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