DNA damage response and Autophagy: a meaningful partnership

Autophagy and the DNA damage response (DDR) are biological processes essential for cellular and organismal homeostasis. Herein we summarize and discuss emerging evidence linking DDR to autophagy. We highlight published data suggesting that autophagy is activated by DNA damage and is required for s...

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Bibliographic Details
Main Authors: ARISTIDES G ELIOPOULOS, Sophia Havaki, Vassilis G Gorgoulis
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2016-11-01
Series:Frontiers in Genetics
Subjects:
Autophagy
Cell Death
DNA Damage
Inflammation
evolution
senescence
Online Access:http://journal.frontiersin.org/Journal/10.3389/fgene.2016.00204/full
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