DNA damage response and Autophagy: a meaningful partnership

Autophagy and the DNA damage response (DDR) are biological processes essential for cellular and organismal homeostasis. Herein we summarize and discuss emerging evidence linking DDR to autophagy. We highlight published data suggesting that autophagy is activated by DNA damage and is required for s...

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Hauptverfasser: ARISTIDES G ELIOPOULOS, Sophia Havaki, Vassilis G Gorgoulis
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2016-11-01
Schriftenreihe:Frontiers in Genetics
Schlagworte:
Autophagy
Cell Death
DNA Damage
Inflammation
evolution
senescence
Online Zugang:http://journal.frontiersin.org/Journal/10.3389/fgene.2016.00204/full
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