Antidepressant-like effect of ginsenoside Rb1 on potentiating synaptic plasticity via the miR-134–mediated BDNF signaling pathway in a mouse model of chronic stress-induced depression

Background: Brain-derived neurotrophic factor (BDNF)–tropomyosin-related kinase B (TrkB) plays a critical role in the pathogenesis of depression by modulating synaptic structural remodeling and functional transmission. Previously, we have demonstrated that the ginsenoside Rb1 (Rb1) presents a novel...

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Bibliographic Details
Main Authors: Guoli Wang, Tianyue An, Cong Lei, Xiaofeng Zhu, Li Yang, Lianxue Zhang, Ronghua Zhang
Format: Artigo
Language:Inglês
Published: Elsevier 2022-05-01
Series:Journal of Ginseng Research
Subjects:
Ginsenoside Rb1
Depression
miR-134
BDNF–TrkB signaling
Synaptic plasticity
Online Access:http://www.sciencedirect.com/science/article/pii/S1226845321000385
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