DNA-based copy number analysis confirms genomic evolution of PDX models

Abstract Genomic evolution of patient-derived xenografts (PDXs) may lead to their gradual divergence away of their tumors of origin. We previously reported the genomic evolution of the copy number (CN) landscapes of PDXs during their engraftment and passaging1. However, whether PDX models are highly...

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Bibliographic Details
Main Authors: Anna C. H. Hoge, Michal Getz, Anat Zimmer, Minjeong Ko, Linoy Raz, Rameen Beroukhim, Todd R. Golub, Gavin Ha, Uri Ben David
Format: Artigo
Language:Inglês
Published: Nature Portfolio 2022-04-01
Series:npj Precision Oncology
Online Access:https://doi.org/10.1038/s41698-022-00268-6
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