Lung-Protective Ventilation Attenuates Mechanical Injury While Hypercapnia Attenuates Biological Injury in a Rat Model of Ventilator-Associated Lung Injury

Background and Objective: Lung-protective mechanical ventilation is known to attenuate ventilator-associated lung injury (VALI), but often at the expense of hypoventilation and hypercapnia. It remains unclear whether the main mechanism by which VALI is attenuated is a product of limiting mechanical...

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Bibliographic Details
Main Authors: Nada Ismaiel, Sara Whynot, Laurette Geldenhuys, Zhaolin Xu, Arthur S. Slutsky, Valerie Chappe, Dietrich Henzler
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2022-04-01
Series:Frontiers in Physiology
Subjects:
lung-protective mechanical ventilation
hypercapnia
ventilator associated lung injury
acute lung injury
mechanical ventilalion
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2022.814968/full
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